A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis.
Neutrophils play a central role in eliminating bacterial pathogens, but may also contribute to end-organ damage in sepsis.Interleukin-8 (IL-8), a key modulator of neutrophil function, signals through neutrophil specific surface receptors CXCR-1 and CXCR-2.In this study a mechanistic computational model was used to evaluate and deploy an extracorpor